A short statement released on the actor’s Facebook page read: “Laurence Fox and Billie Piper have separated. No third parties involved. For the sake of our family we request and appeal for space and privacy at this time.”
Billie and the Lewis actor, 37, have two sons Winston, seven and Eugene, three. They met while starring in a play called Treats together in 2006 and married at the 12th century parish church of St Mary's in Easebourne, West Sussex, near the family home on New Year's Eve in 2007.
Fox previously described it was "love at first sight" when he met Billie.
"It absolutely happened when I met Bill. We were in a rehearsal room and I knew there and then she was the one for me," he said in an interview in 2010.
While appearing on GMTV back in 2008, the actor revealed how the couple shared a "drunken lunch" during their honeymoon in Mexico and ending up getting matching tattoos to mark their marriage.
The actor's tattoo, which is inked on his forearm, reads: "Mrs Fox 31st December 2007", while hers reads: "Mr Fox 31 December 2007".
In March, Fox described his perfect evening with Dr Who actress Billie.
In an interview, he said: "Sitting next to my wife, watching telly, taking it easy with a glass of wine and a Thai chilli and basil stir-fry chicken.That's one of my signature dishes, so I cook it. But she's a great cook, too."
Also in March, Fox stunned theatregoers by launching into a foul-mouthed attack on a heckler before walking off stage during a live performance at a London theatre.
he actor, who was playing Charles de Gaulle in The Patriotic Traitor, scolded a man sitting in the front row who had snubbed him.
Fox was heard to say: “I won’t bother telling you the story because this c*** in the front row has ruined it for everybody.”
He then left the stage and was absent when the rest of the cast came on for their bow after the show at the Park Theatre in Finsbury Park.
The actor later apologised to the "other 199 people in the theatre" and said he was "very upset" about how he had behaved, admitting that he should have dealt with the interuption in a different way.
Piper, star of Secret Diary Of A Call Girl, was previously married to presenter Chris Evans, to whom she tied the knot in 2001 after a six-month romance.
Their relationship was a controversial one at the time: she was just 19 years old when she married Chris, who was 35 at the time.
They split in 2004 and finally divorced in 2007, just months before she made it official with Laurence, and they have remained close friends
